Ozempic Side Effects

Ozempic (semaglutide) is a medication used to treat type 2 diabetes. It works by lowering blood sugar levels and promoting weight loss. While Ozempic can be an effective treatment option, it can also cause side effects. Here are some short-term and long-term side effects of Ozempic:

Short-Term Side Effects

Short-term side effects are those that occur within a few days or weeks of starting Ozempic treatment. These side effects usually go away on their own as your body adjusts to the medication. Common short-term side effects of Ozempic include:

Gastrointestinal Effects

Ozempic works by mimicking a hormone that lowers blood sugar, which can cause gastrointestinal effects. Here’s how it can lead to specific symptoms:

  • Nausea: Ozempic can slow down stomach emptying, making you feel full or nauseous.
  • Vomiting: In some cases, nausea can progress to vomiting.
  • Diarrhea: Ozempic can increase the amount of water in your intestines, leading to loose or watery stools.
  • Abdominal pain: Digestive changes caused by Ozempic can lead to cramps, discomfort, or pain in the abdomen.
  • Constipation: While Ozempic can cause diarrhea in some people, it can also lead to constipation in others due to slower digestion.
Ozempic side effects: person suffering from abdominal pain

If you experience gastrointestinal side effects while taking Ozempic, talk to your doctor. They may recommend adjusting your dosage or taking steps to manage your symptoms, such as drinking more water, eating smaller meals, or avoiding high-fat foods.

Injection Site Reactions

Ozempic is administered via injection, which can cause local irritation or inflammation. Here’s how it can lead to specific injection site reactions:

  • Redness: Ozempic can cause redness or warmth at the injection site due to inflammation.
  • Swelling: The injection can trigger an immune response, leading to swelling or a raised bump.
  • Itching: It’s possible to experience mild itching or irritation at the injection site.
  • Bruising: Ozempic can cause bleeding or bruising under the skin if the needle hits a blood vessel.

If you experience injection site reactions, try massaging the area gently or applying a warm compress to reduce inflammation. Avoid injecting into the same spot repeatedly, and make sure you’re following proper injection technique.

If your symptoms persist or worsen, talk to your doctor. They may recommend an alternative injection site or suggest a different treatment.

Other Side Effects

In addition to gastrointestinal and injection site reactions, Ozempic can cause other short-term side effects. Here’s how it can lead to specific symptoms:

  • Headache: Ozempic can cause headaches due to changes in blood sugar levels or hormonal fluctuations.
  • Dizziness: It’s possible to feel lightheaded or dizzy when taking Ozempic, especially if you stand up quickly.
  • Fatigue: Some people may experience fatigue or low energy while taking Ozempic.
  • Low blood sugar (hypoglycemia): Ozempic works by lowering blood sugar, which can cause hypoglycemia if levels drop too low. Symptoms can include shakiness, sweating, confusion, or fainting.
Ozempic side effects: woman suffering from headache

If you experience these or other short-term side effects, talk to your doctor. They may recommend adjusting your dosage or suggest ways to manage your symptoms. It’s also important to monitor your blood sugar levels regularly and seek medical attention if you experience severe or persistent symptoms of hypoglycemia.

Long-Term Side Effects

Long-term side effects are those that can occur after months or years of taking Ozempic. While some long-term side effects are not serious, others can be life-threatening. Long-term side effects of Ozempic include:


Ozempic has been associated with an increased risk of pancreatitis, which is inflammation of the pancreas. Here’s how it can lead to specific symptoms:

  • Inflammation of the pancreas: Ozempic can cause irritation or damage to the pancreas, leading to inflammation and potential long-term damage.
  • Severe abdominal pain: Pancreatitis can cause severe pain in the upper abdomen that may radiate to the back or chest.
  • Nausea: Inflammation of the pancreas can lead to nausea or vomiting.
  • Vomiting: Some people with pancreatitis may experience vomiting, which can further exacerbate dehydration and other symptoms.

If you experience severe abdominal pain or other symptoms of pancreatitis, seek medical attention immediately. Pancreatitis can be a serious condition that requires prompt treatment, and Ozempic may need to be discontinued or adjusted.

If you have a history of pancreatitis or other pancreatic disorders, make sure to discuss this with your doctor before starting Ozempic.

Kidney Damage

Long-term use of Ozempic has been associated with an increased risk of kidney damage. Here’s how it can affect kidney function:

  • Decreased kidney function: Ozempic may cause a decline in kidney function over time, particularly in people with pre-existing kidney disease.
  • Increased risk of kidney disease: People taking Ozempic may be at an increased risk of developing kidney disease, particularly if they have other risk factors such as high blood pressure or diabetes.

If you have a history of kidney disease or other kidney problems, talk to your doctor before starting Ozempic. They may recommend regular monitoring of your kidney function or suggest alternative treatments.

If you experience symptoms such as swelling in the feet or ankles, changes in urine output, or difficulty breathing, seek medical attention immediately as these may be signs of kidney damage.

Thyroid Cancer

There have been concerns about the potential risk of thyroid cancer associated with long-term use of Ozempic. Here’s how it can manifest:

  • Increased risk of thyroid cancer: Studies have shown a small but increased risk of thyroid cancer in people taking Ozempic over a long period of time.
  • Lump or swelling in the neck: Thyroid cancer can cause a lump or swelling in the neck, often near the thyroid gland.
  • Hoarseness or difficulty speaking: In some cases, thyroid cancer can affect the vocal cords, leading to hoarseness or difficulty speaking.

It’s important to note that the risk of thyroid cancer with Ozempic use is still being studied, and it may not be a significant concern for most people.

Ozempic side effects: woman suffering from pain in throat

However, if you have a family history of thyroid cancer or other thyroid problems, or if you notice any lumps or swelling in your neck, talk to your doctor. They may recommend regular monitoring or further evaluation to ensure your thyroid is functioning properly.

Diabetic Retinopathy

Diabetic retinopathy is a potential long-term side effect of Ozempic use that affects the blood vessels in the retina. Here’s how it can occur:

  • Damage to the blood vessels in the retina: Over time, high blood sugar levels can damage the small blood vessels in the retina, leading to diabetic retinopathy.
  • Blurred vision: As the condition progresses, you may experience blurred vision or difficulty seeing clearly.
  • Blindness: In severe cases, diabetic retinopathy can cause permanent vision loss and even blindness.

It’s important to have regular eye exams if you’re taking Ozempic, especially if you have a history of diabetes or other risk factors for diabetic retinopathy. Your doctor may recommend additional measures to help prevent this condition, such as controlling your blood sugar levels, maintaining a healthy diet and exercise routine, and quitting smoking.

If you experience any changes in your vision, such as blurred or distorted vision, contact your doctor right away.

Cardiovascular Effects

Ozempic can cause long-term side effects like cardiovascular effects, which affect the heart and blood vessels:

  • Heart attack: Ozempic may increase the risk of heart attacks, especially in people with a history of heart disease.
  • Stroke: It can also increase the risk of stroke, which occurs when a blood vessel in the brain is blocked or bursts.
  • High blood pressure: Ozempic may raise blood pressure, making the heart work harder to pump blood.
A doctor holding a model heart in hand

To reduce the risk of cardiovascular effects, it’s important to follow a healthy lifestyle, including regular exercise, healthy eating, and not smoking. Talk to your doctor if you have a history of heart disease or other cardiovascular conditions.


In conclusion, while Ozempic can be an effective treatment for type 2 diabetes, it may cause both short-term and long-term side effects. Short-term effects include gastrointestinal reactions, injection site reactions, and other side effects like headaches, dizziness, fatigue, and low blood sugar.

Long-term effects include pancreatitis, kidney damage, thyroid cancer, diabetic retinopathy, and cardiovascular effects such as heart attacks, strokes, and high blood pressure.

It’s important to weigh the benefits of Ozempic against the potential risks and talk to your doctor about any concerns. With proper monitoring and management, many of these side effects can be avoided or minimized.